I tried that on an ‘old’ one: 3.6.1, but there shouldn’t be any difference with 3.6.5
But this sort of thing can be really tricky to solve. I had about 30 spikes on both the mouth and the eyes (on my own model)….I managed to fix them eventually, but it was a lot of going back and forth between smoothing, switching Shapekey and smoothing again…In my experience, smoothing, then Saving and then switching seemed to make it worse.