I think we are talking about a different aspect of object completely. By my question #1 I mean that right now my topology is designed like this:


where there is a ring of faces around each of the holes.
Your initial suggestion about this front side with the C hole flows similarly but to my eye has a vertical flow instead of horizontal:

however your holes have a completely different flow:

which if applied to my clamp would look more like:


Does this help clarify what I mean by the first question?
At this stage I’m asking about the basic flow of vertexes on the 2D planes of the faces of the object, not about creating edges, seams, thickness, bevels, smooth corners, or anything like that (though I do thank you for your time commenting on those topics). I’m asking only about the way the flow of quads is laid out.