Yes, I agree with @blanchsb. I had this happen to me and it was the face normals being inverted. You can view your face normals this way. Red means the faces are facing inward and blue means they are facing outward. You want blue.

If you need a more explicit way to view the normals, you can view it in Edit mode and in this window:

The way the line points is the way the normal is facing.
That would be the first thing to check and reimport to Substance.