@jesse94 You certainly can do that. VirtualBox is a great choice. The extension pack makes it possible to use your mouse and keyboard and other USB devices inside your virtual machine( your Windows 10 or Linux or whatever you want to use to run Blender in), so you will need that!
Make sure to give the virtual machine enough GB, but if you only use the windows 10 to run Blender, 16GB should be enough.
I haven’t used VirtualBox in a while, so I don’t remember everything, but it works fine and it has good documentation.
You will also easily be able to find tutorials on how to install and use it.
Good luck!
