The actual answer is “It depends”. In this particular case, it is easier to ratio the build. Meaning that you are working with larger scale than it really is. You are using the reference image as the base unit instead of Micro/macro/milli meters. Then if you need more reallistic lighting and camera work then you would scale it. Why? it has to do with CPU and/or GPU percision also referred to as rounding errors. When you get smaller than 0.0001 of a meter rounding errors can occur and cause weird and unexpected problem. Again this depends on your CPUs and/or GPUs percision. If it’s high then you may never experience a problem. If it’s low then you may experience a lot of problems.