For sure unwrapping dense models is a no go. That is why you don’t see sculpts getting unwrapped and pushed down the pipeline. You need to have a clean mesh, otherwise is a total nightmare. So unless you’re just showcasing the model just because you want to show it or a client has to approve, a mesh with high density should only be used for showcasing, not to push it through the actual production process of unwrapping, UV’ing, texturing, etc. If you’re going down that line, it’s better to retopo.
