Yes it does, if you only have one GPU , then it will be devoting most of its power to rendering and thus your UI will slow right down. Personally , I have 4 GPU’s , and these days , you can tell Blender which ones to use for rendering, so If I am at the computer while rendering, ill tell Blender to only use the other 3 GPU’s and keep the display one free so I can continue to work, but if I can leave the computer to render , Ill set all 4.
It is a huge advantage having multiple GPU’s if you are rendering a lot whilst you want to keep working on the computer.
Also , if you have any issues with the Piero course, give me a shout and ill see if I can help. My model is fully textured and rigged , although I have yet to animate it.
Good luck!