From the hardware side, nothing, you got a powerful computer. So your attention should be on the optimization of your scene and Blender settings. You have to take into account the poly count, save polygons where ever you can, light bounces, if your scene is trapped in a room or on the open space of the 3D view, if you are linking in assets to save memory, if you are breaking your scene into render layers, resolution of your textures, etc.
