Hi @grlkrash
Yeah we might need a little more information to be able to help diagnose the issue.
But here are some possible causes.
-the bones are not set to deform
-the armature modifier isn’t active on the mesh
-the armature is in “rest position” (only if you pressed that button)
-there’s some spelling mistakes in the vertex group names and they don’t match the names of the bones
-Gremlins……sometimes the answer is Gremlins.