Ok may I ask what model Wacom you’re using? I think it will make things easier to explain. Some generic tips: if your device has buttons and a scroll wheel on the side, make use of them! Assign them shortcuts like CTRL, SHIFT, ALT, and TAB. Use the scroll wheel for brush size adjustment. Set your pen buttons to right and middle mouse. Then flip your tablet so that the buttons are on the right.
If you have a display that is just a screen and no buttons, WACOM has grid overlay settings for touch. Set your shortcuts on these overlay grids. There should be a way to toggle them on and off, and use these instead of physical buttons.
