Yes, that’s how I’ve been using retopology myself until now. I create a sculpture and then the retopologized low-res mesh. Afterwards, I bake a normal map and apply it to the low-res mesh. But while this approach produces decent results, it has its limitations. And I still need to be able to create those detailed sculptures in the first place. Multi-resolution modifier sounds like a good suggestion and I’ll definitely have a look at it when I’m sculpting again.